‘Yes, that is certainly about right. I seek out a Actual physical understanding of Organic units inside a base-up way. I do think you can distinguish 3 strains of study in my group in the mean time. The 1st worries chromosome framework: How will you get a metre-prolonged DNA polymer folded and organised in this kind of microscopic mobile? We've produced visualisation approaches that allow us to study how, one example is, SMC proteins loop DNA (movie on Youtube) in order to Construct up chromosomes.
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2007, initial authentic-time detection of strand Trade in homologous recombination by RecA; discovery of a lower persistence duration of ends of microtubules; and settled the system of biosensing with carbon nanotubes
2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and very first ever review from the dynamics DNA supercoils and the invention of supercoil hopping
Immediate immobilization of native yeast iso-one cytochrome c on bare gold: rapid electron relay to redox enzymes and zeptomole protein-film voltammetry
Because 2000 he moved to single-molecule biophysics and nanobiology, with investigate from DNA supercoiling scientific tests of nucleosomes and DNA mend proteins to DNA translocation by means of nanopores. Lately his research has focused on studying mobile division with bacteria on chip, although his greatest curiosity is within the course of realizing artificial cells.
Atomic pressure microscopy reveals that vaccinia topoisomerase IB generates filaments on DNA inside a cooperative trend
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Presently, we also recognized that it should be achievable to utilize an individual semiconducting carbon nanotube to produce a transistor — and we set out to really make it. We stretched unique semiconducting nanotubes throughout metallic electrodes and utilised the underlying silicon substrate as being a gate electrode, establishing The essential 3-terminal format of a industry-influence transistor (Fig.
Considering that 2000 he moved to single-molecule biophysics and nanobiology, with exploration from scientific studies of DNA loop extrusion and supercoiling to DNA translocation through nanopores. Additional not too long ago his research has centered on studying chromatin construction and mobile division with microorganisms on chip, while he can be attempting to eventually Construct artificial cells from the bottom up.
Cees Dekker is Distinguished College Professor at TU Delft. Trained as a physicist, he pioneered nanotechnology with numerous discoveries on carbon nanotubes within the 1990s. Because 2000, he moved to single-molecule biophysics and nanobiology. His current research concentrates on (i) nanopores for protein sequencing; (ii) chromosome composition, specifically SMC motor protein; and (iii) creating a living synthetic mobile from lifeless molecules. Dekker can be an elected member with the KNAW and fellow on the APS plus the IOP.
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Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij ceesdekker al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij satisfied enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond smart design in 2005. (nl)